Ag(I)/Lewis Acid Cooperatively Promoted Three-Component Coupling for Carbo-Heterofunctionalization of Alkenes
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作者
Tao, Yigao; Hu, Rong; Jie, Xiaoming; Su, Weiping
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刊物名称
ACS CATALYSIS
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年、卷、文献号
2022, 12, 2155-5435
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关键词
Tao, Yigao; Hu, Rong; Jie, Xiaoming; Su, Weiping
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摘要
A silver oxidant/Lewis acid catalyst cooperatively promoted three-component carbo-heterofunctionalization of alkenes is reported. A broad range of nucleophiles, including H2O, alcohols, and anilines, can combine with a variety of 1,3-dicarbonyl compounds or analogues as radical precursors to realize difunctionalization of various styrene derivatives. Interestingly, mechanistic investigations demonstrate that the Ag(I) complex of bidentate phosphine ligand quickly oxidizes the radical intermediate generated from the addition of initial radical across alkene double bonds to form carbocation intermediates, which may be the reason behind the excellent yields and high selectivity of such reactions.
