DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity
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作者
Zhao, Yan; Guo, Linjie; Cao, Shuting; Xie, Mo; Peng, Hongzhen; Li, Jiang; Luo, Shihua; Ma, Lan; Wang, Lihua
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刊物名称
CHEMICAL COMMUNICATIONS
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年、卷、文献号
2022, 59, 1359-7345
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关键词
Zhao, Yan; Guo, Linjie; Cao, Shuting; Xie, Mo; Peng, Hongzhen; Li, Jiang; Luo, Shihua; Ma, Lan; Wang, Lihua
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摘要
We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.
