Radical-Induced Metal-Free Alkynylation of Aldehydes by Direct CH Activation
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作者
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刊物名称
Chem.-Eur. J.
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年、卷、文献号
2015, 21,
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关键词
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摘要
A direct C(sp(2))H alkynylation of aldehyde C(O)H bonds with hypervalent iodine alkynylation reagents provides ynones under metal-free conditions. In this method, 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) constitutes an efficient alkynylation reagent for the introduction of the triple bond. The substrate scope is extended to a variety of (hetero)aromatic, aliphatic, and ,-unsaturated aldehydes.
