中国科学院上海高等研究院研究生教育

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副研究员
zhangbg@sari.ac.cn
上海市浦东新区海科路99号2号楼
200120

张保国，男，副研究员，研究生导师。2011年9月入职高研院。2008年7月于中科院生态环境研究中心中科院环境生物技术重点实验室获博士学位，2008年11月至2011年9月中科院上海生命科学研究院营养科学研究所从事博士后研究，2011年9月起在中科院上海高等研究院生物炼制实验室担任副研究员。相关研究成果发表SCI 收录研究论文19篇，申请国家发明专利12 项，参与编写英文论著1部。

1.微生物细胞工厂的代谢调控

2.重要医药中间体/生物活性物质的微生物合成生物技术

3.应用环境生物技术

赛诺菲·安万特-中国科学院上海生命科学研究院优秀青年人才奖励基金

1.国家重点研发计划，“农业生产副产物和废弃物高值化利用生物技术开发”，项目负责人，2018.07-2021.06；

2.国家重点研发计划，“农业废弃物资源化利用机制”，子课负责人， 2017.01-2021.06；

3.国家重点研发计划，“黄淮海蔬菜主产区面源污染综合防治技术示范”，参与，2018.07-2021.06；

4.中科院STS区域重点项目，“农业有机废物资源化成套利用技术与模式示范”，课题负责人，2020.01-2021.12；

5.福建省中科院STS重大项目，“生物法高效制备食品级L-酪氨酸产业化技术研究与应用”，课题负责人，2022.03-2025.3；

6.云南科技厅，“新型肥料增效剂生物合成关键技术研究”，课题负责人，2022.03-2024.12；

7.地方横向，“DHA（二羟基丙酮）生产菌种研发”，项目负责人，2022.06-2024.05；

8.地方横向，“高活性糖基转移酶微生物细胞工厂构建”，项目负责人，2021.12-2024.12；

9.地方横向，“高产生物活性物质微生物细胞工厂构建”，项目负责人，2021.11-2024.10；

10.地方横向，“生物催化法合成γ-氨基丁酸工艺开发”，项目负责人，2021.07-2023.06；

11.地方横向，“代谢工程改造微生物制备关键甾体药物中间体技术开发”，项目负责人，2020.06-2023.5；

12.地方横向，“生转催化法转化雄烯二酮（4-AD）制备雄二烯二酮（ADD）工艺开发”，项目负责人，2019.03-2024.03。

1. 文章：

[1]Xiangcen Liu, Jingxian Zhang, Cenyang Yuan, Suwan Han, Guilin Du, Jiping Shi, Junsong Sun, BaoguoZhang*. Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ1 -dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum. Microbial Cell Factories，2023，22（53）

[2]Chenyang Yuan, Zhiguo Ma, Yixin Li, Jingxian Zhang, Xiangcen Liu, Suwan Han, Guilin Du, Jiping Shi, Junsong Sun, BaoguoZhang*. Production of 21？hydroxy？20？methyl？pregna？1,4？dien？3？one by modifying multiple genes in Mycolicibacterium. Applied Microbiology and Biotechnology, 2023,107(5-6):1563-574）

[3]Yuan, Chenyang， Li, Yixin，Han, Suwan，He, Beiru，Zhai, Xinghui，Lin, Weichao，Shi, Jiping，Sun, Junsong，Zhang, Baoguo*. Functional analysis of acyl-CoA dehydrogenases and their application to C22 steroid production. Applied Microbiology and Biotechnology. 2023，107：3419–3428;

[4]Jingxian Zhang，Ruijie Zhang，Shikui Song，Zhengding Su，Jiping Shi，Huijin Cao and Baoguo Zhang*. Whole-Genome Analysis of Mycobacterium neoaurum DSM1381 and the Validation of Two Key Enzymes Affecting C22 Steroid Intermediates in Sterol Metabolism. International Journal of Molecular Sciences. 2023, 24：6148；

[5]Chenyang Yuan, Shikui Song, Jianxin He, Jingxian Zhang, Xiangcen Liu , Eliana L

Pena, Junsong Sun, Jiping Shi, Zhengding Su, Baoguo Zhang* . Bioconversion of Phytosterols to 9-Hydroxy-3-Oxo-4,17-Pregadiene-20-Carboxylic Acid Methyl Ester by Enoyl-CoA Deficiency and Modifying Multiple Genes in Mycolicibacterium neoaurum. Applied and Environmental Microbiology，2022,88(22):e0130322）

[6]GuilinDu，YanZhou，JingxianZhang，SuwanHan，XiangcenLiu，henyangYuan，Fabrice Ndayisenga，JipingShi*，BaoguoZhang*. Optimized strategy valorizing unautoclaved cottonseed hull as ruminant alternative feeds via solid-state fermentation: Detoxifying polyphenols, restraining hazardous microflora and antibiotic-resistance gene hosts. Environmental Technology & Innovation. 2022，28：102937

[7]Yuan Chen-Yang, Ma Zhi-Guo, Zhang Jing-Xian, Liu Xiang-Cen, Du Gui-Lin, Sun Jun-Song*, Shi Ji-Ping, Zhang Bao-Guo*. Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment. Microbial Cell Factories, 2021,12,6；

[8]Jingxian Zhang, Jiping Shi, Chenyang Yuan, Xiangcen Liu, Guilin Du, Ruimei Fan*, Baoguo Zhang*. MicroRNA Expression Profile Analysis of Chlamydomonas reinhardtii during Lipid Accumulation Process under Nitrogen Deprivation Stresses. Bioengineering (Basel),2021, 27;9(1):6;

[9]Xu Zhang, Yu-Mei Huang,Hua-Li Qin*, Zhang Baoguo*, K. P. Rakesh, Haolin Tang. Copper-Promoted Conjugate Addition of Carboxylic Acids to Ethenesulfonyl Fluoride (ESF) for Constructing Aliphatic Sulfonyl Fluorides, ACS Omega , 2021, 6, 40, 25972–25981;

[10]Haiyan Duan, Minghua Ji, Yukang Xie, Jiping Shi, Li Liu, Baoguo Zhang*, Junsong Sun* . Exploring the Microbial Dynamics of Organic Matter Degradation and Humification during Co-Composting of CowManure and Bedding MaterialWaste, Sustainability , 2021, 13(23), 13035;

[11]Guilin Du, Wenwen Feng, Hanbin Cai2, Zhiguo Ma, Xiangcen Liu, Chenyang Yuan, Jiping Shi *, Baoguo Zhang* Exogenous Enzymes Amendment Accelerates Maturity and Changes Microflora Succession in Horse and Wildlife Animal Manures Co-composting. Environmental Science and Pollution Research，2021,28, 21610-21620.

[12]Du, Guilin; Shi, Jiping; Zhang, Jingxian; Ma, Zhiguo; Liu, Xiangcen; Yuan, Chenyang; Zhang, Baoguo*; Zhang, Zhanying; Harrison, Mark D. Exogenous Probiotics Improve Fermentation Quality, Microflora Phenotypes, and Trophic Modes of Fermented Vegetable Waste for Animal Feed, Microorganisms, 2021, 9(3): 644.

[13]Du, Guilin; Zhang, Guilong; Shi, Jiping; Zhang, Jingxian; Ma, Zhiguo; Liu, Xiangcen; Yuan, Chenyang; Li, Xiang*; Zhang, Baoguo*. Keystone Taxa Lactiplantibacillus and Lacticaseibacillus Directly Improve the Ensiling Performance and Microflora Profile in Co-Ensiling Cabbage Byproduct and Rice Straw, Microorganisms , 2021, 9, (5): 1099.

[14]Xiangcen Liu, Ruijie Zhang, Zhiwei Bao, Chenyang Yuan, Huijin Cao, Jiping Shi, Junsong Sun*, Baoguo Zhang*. Biotransformation of phytosterols to ADD by Mycobacterium sp. ZFZ expressing 3-ketosteroid-Δ1-dehydrogenase. Catalysts, 2020,doi: 10.3390/catal10060663.

[15]Ruijie Zhang, Xuexia Xu, Huijin Cao, Chenyang Yuan, Yuki Yuminaga, Suwen Zhao, Jiping Shi*, Baoguo Zhang*.Purification, characterization, and application of a high activity 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum DSM 1381.Applied Microbiology and Biotechnology,2019, DOI: 10.1007/s00253-019-09988-5.

[16]Chengyu Yang, Weiming Fan, Ruijie Zhang, Jiping Shi, Zorica Kne？evi？-Jugovi？, Baoguo Zhang*. Study on Transglucosylation Properties of Amylosucrase from Xanthomonas campestris pv. Campestris and Its Application in the Production of α-arbutin. Catalysts, 2019, 9(1), 5, DOI: 10.3390/catal9010005.

[17]Ruijie Zhang, Xiangcen Liu, Yushi Wang, Yuchang Han1, Junsong Sun, Jiping Shi*, Baoguo Zhang*. Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons. Microbial Cell Factories, 2018,18;17(1):77. doi: 10.1186/s12934-018-0916-9.

[18]Baoguo Zhang, Ruimei Fan, Zhihui Bai , Shan Wang,Liang Wang,Jiping Shi, Biosorption characteristics of Bacillus gibsonii S-2 waste biomass for removal of lead (II) from aqueous solution. Environ Sci Pollut Res, 2013,20(3)1367-73;

[19]Baoguo Zhang, Zhihui Bai, Daniel Hoefel, Guoqiang Zhuang, Hongxun Zhang. Assessing the impacts of the biological control agent Bacillus thuringiensis on the indigenous microbial community within the pepper plant phyllosphere. FEMS Microbiol Lett, 2008,284: 102-108;

[20]Baoguo Zhang, Zhihui Bai, Daniel Hoefel, Ling Tang, Xiaoyi Wang, Baoju Li, Guoqiang Zhuang. The impacts of cypermethrin pesticide application on the non-target microbial community of the pepper plant phyllosphere. Sci Total Environ, 2009,407: 1915-1922;

[21]Baoguo Zhang, Hongxun Zhang, Bo Jin, Ling Tang, Baoju Li, Guoqiang Zhuang, Zhihui Bai. Effect of cypermethrin insecticide on the microbial community in cucumber phyllosphere. J Environ Sci, 2008,20:1356-1362 ;

[22]Zuming L, Zhihui Bai, Baoguo Zhang, Baojv Li, Bo Jin, Michael Zhang, Francis Lin , Hongxun Zhang. Purification and characterization of alkaline pectin lyase from a newly isolated Bacillus clausii and its application in elicitation of plant disease resistance. Appl Biochem Biotechnol, 2012,167(8):2241-2256;

[23]Yuanfan Hong, Zhongjian Chen, Baoguo Zhang, Qiwei Zhai. Isolation of Photobacterium sp. LuB-1 and its application in rapid assays for chemical toxicants in water. Lett Appl Microbial, 2010,51:308-312;

Zhiguang Yang, Baoguo Zhang, Xi Chen, Zhihui Bai, Hongxun Zhang. Study on pyrolysis of wheat straw residues from ethanol production by solid-state fermentation. J Anal Appl Pyrolysis, 2008,81:243-246.

2. 论著章节

[1] Baoguo Zhang, Zhihui Bai, Daniel Hoefel, Xiaoyi Wang, Zuming Li. Microbial diversity within the phyllosphere of different vegetable species. In: Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology (A. Méndez-Vilas, eds.). Formatex Research Center, 2010, 1067-1077;

3. 专利

[1]张保国；韩苏皖；刘相岑；张静娴；杜桂林；翟星荟；贺蓓茹；史吉平；制备甾体药物中间体雄烯二酮和双降醇的基因工程菌、及制备甾体药物中间体雄烯二酮和双降醇的方法，申请号，：2023103063213；

[2]张保国; 刘相岑; 张静娴; 韩苏皖; 杜桂林; 史吉平 ; 一种用于生产制备9-OHAD的基因工程菌株、及其制备方法和应用, 申请号, 2023100395556；

[3]张保国；袁辰阳；刘相岑；张静娴；杜桂林；韩苏皖；史吉平；一种产甾药前体的基因工程菌及其用途，专利授权号：ZL202210730036X；

[4]张保国；刘相岑；袁辰阳；张静娴；杜桂林；韩苏皖；史吉平；一种产双降醇的基因工程菌及其用途，申请号：2022107293262；

[5]张保国；杜桂林；史吉平；袁辰阳；刘相岑；张静娴；韩苏皖；一种反刍动物用的棉籽壳发酵饲料及其制备方法，专利授权号：2022105855710；

[6]张保国；杜桂林；刘相岑；袁辰阳；马治国；史吉平一种畜禽用的尾菜发酵饲料及其制备方法，申请号：2020106429336；

[7]张保国；刘相岑；袁辰阳；曹慧锦；杜桂林；史吉平，一种微生物降解植物甾醇生产雄二烯二酮的方法，专利申请号2020106989338;

[8]张保国；张瑞婕；刘向岑；韩煜畅；史吉平；姜标，一种3-甾酮-△1-脱氢酶及其编码基因和应用，授权专利号：ZL201810200187.8；

[9]张保国，魏长龙，曾俊华，王珊，史吉平，姜标. 一种微生物转化制备9α-羟基-雄烯二酮的工艺方法. 中国发明专利，授权专利号ZL201310342583.1。